Abstract
Abstract. This study provides an integrated evaluation of psychosomatic characteristics and microelement status in pediatric patients with atopic dermatitis (AD), emphasizing the diagnostic relevance of anxiety indicators alongside zinc and magnesium levels. Situational and personal anxiety were assessed using the Spielberger–Hanin scale, while disease severity was quantified with the SCORAD index. Serum zinc and magnesium concentrations were analyzed to determine microelement balance. The majority of children exhibited increased anxiety levels that were positively associated with the extent of dermatological involvement, as well as deficiencies of zinc and magnesium linked to intensified inflammatory activity and diminished stress tolerance. A combined analysis of psychoemotional and metabolic parameters enhances diagnostic precision and supports a more personalized and effective strategy for the clinical management of children with AD.
References
1. Zhukova M.V. The role of magnesium in the regulation of the nervous system in children with chronic dermatoses. Pediatrics. Journal named after G.N. Speransky. 2020;99(4):78–84.
2. Kubanova L.N., Kubanov A.A., Bogdanova E.V. Atopic dermatitis in children: modern approaches to diagnosis and therapy. Russian Journal of Skin and Venereal Diseases. 2018;21(2):105–112.
3. Khaikina E.V., Fedoseeva E.A. Disorders of microelement metabolism in children with atopic dermatitis. Bulletin of Dermatology and Venereology. 2019;95(3):45–52.
4. Bieber T. Atopic dermatitis. The New England Journal of Medicine. 2008;358(14):1483–1494. doi:10.1056/NEJMra074081
5. Di Filippo L., Dréno B., Agrawal R. The role of trace elements (zinc, magnesium) in atopic dermatitis: current evidence and clinical perspectives. Journal of Dermatological Science. 2020;98(3):123–130. doi:10.1016/j.jdermsci.2020.04.012
6. Gröber U., Werner T., Vormann J., Kisters K. Magnesium and skin health: a review of the literature. Nutrients. 2017;9(6):646. doi:10.3390/nu9060646
7. Mirrakhimova M.Kh., Khalmatova B.B., Nishonboyeva N.Y. Clinical and diagnostic aspects of atopic dermatitis in pediatric patients in Uzbekistan. The American Journal of Medical Sciences and Pharmaceutical Research. 2021;3(3):132–140. doi:10.37547/TAJMSPR/Volume03Issue03-19
8. Misery L., Skroza N., Ständer S., et al. Psychodermatology in childhood and adolescence: clinical aspects and therapeutic approaches. Dermatology. 2019;235(6):430–438. doi:10.1159/000499456
9. Prasad A.S. Zinc in human health: effect on immune function. Molecular Medicine. 2008;14(5–6):353–357. doi:10.2119/2008-00033.Prasad
10. Wollenberg A., Barbarot S., Bieber T., et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: European Academy of Allergy and Clinical Immunology (EAACI). Allergy. 2020;75(12):3295–3311. doi:10.1111/all.14459