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Abstract
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by profound disturbances of the hemostatic system that play a pivotal pathogenetic role in the development of cardiovascular complications. This systematic literature review summarizes the molecular mechanisms underlying hypercoagulability, activation of the coagulation cascade, hypofibrinolysis, endothelial dysfunction, platelet hyperactivity, and neutrophil extracellular trap formation (NETosis) in patients with T2DM. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The analyzed evidence demonstrates that these abnormalities constitute an interconnected and complex pathogenetic network contributing to diabetic thromboinflammation. A comprehensive understanding of these mechanisms provides a theoretical basis for the development of novel diagnostic biomarkers and targeted therapeutic strategies aimed at reducing thrombotic complications in patients with T2DM.References
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