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Abstract
Ushbu maqolada arterial gipertoniya rivojlanishida endoteliy disfunktsiyasining asosiy patofiziologik mexanizmlari o‘rganildi. Tadqiqotning maqsadi — endoteliy tomonidan ishlab chiqariladigan asosiy vasoaktiv moddalar (nitrit oksid (NO), endotelin-1, prostatsiklin) muvozanatining buzilishi natijasida qon tomir tonusi va periferik qarshilikda yuzaga keladigan o‘zgarishlarni tahlil qilishdan iborat. Maqolada oksidlanish stressining kuchayishi, erkin radikallar ta’sirida NO sintezining kamayishi va endotelin-1 sekretsiyasining ortishi natijasida yuzaga keladigan endotelial disfunktsiya mexanizmlari yoritilgan. Shu jarayonlar natijasida qon tomirlarning torayishi, devor elastikligining pasayishi va arterial bosimning doimiy oshib borishi kuzatiladi. Tadqiqot natijalari endoteliy disfunktsiyasi arterial gipertoniya patogenezining markaziy bo‘g‘ini ekanligini ko‘rsatadi. Endoteliy faoliyatini tiklashga qaratilgan antioksidant terapiya va NO-donor preparatlar gipertoniya profilaktikasida samarali yo‘nalish sifatida ko‘rib chiqiladi.
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